The role of IGRA in people living with HIV who
are infected with M. tuberculosis with or without
active TB; information is needed about the
association between performance of IGRA and
immune status.
• The use of TST testing in people living with HIV
and receiving ART, with a particular emphasis on
the frequency of performing TST to determine
immune reconstitution and/or boosting in those
who were initially TST negative.
• What is the optimal TB screening algorithm to
be used across different settings with different
TB and HIV disease burdens to safely initiate
preventive therapy.
• The optimal frequency of screening people
with HIV for active TB with a symptom-based
questionnaire.
• Evaluation of the WHO-recommended algorithm
to diagnose TB using new technological advances
such as LED microscopy, rapid culture and
polymerase chain reaction (PCR)-based methods
• Further validation of the screening algorithm in
various programmatic settings.
• Effect of ICF on nosocomial transmission, in
particular, among people living with HIV, healthcare
workers and/or their families.
• Optimal diagnostic algorithm for diagnosis of TB
following TB screening for IPT
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