Wednesday, June 13, 2012

The role of IGRA in people living with HIV who

The role of IGRA in people living with HIV who
are infected with M. tuberculosis with or without
active TB; information is needed about the
association between performance of IGRA and
immune status.
• The use of TST testing in people living with HIV
and receiving ART, with a particular emphasis on
the frequency of performing TST to determine
immune reconstitution and/or boosting in those
who were initially TST negative.
• What is the optimal TB screening algorithm to
be used across different settings with different
TB and HIV disease burdens to safely initiate
preventive therapy.
• The optimal frequency of screening people
with HIV for active TB with a symptom-based
questionnaire.
• Evaluation of the WHO-recommended algorithm
to diagnose TB using new technological advances
such as LED microscopy, rapid culture and
polymerase chain reaction (PCR)-based methods
• Further validation of the screening algorithm in
various programmatic settings.
• Effect of ICF on nosocomial transmission, in
particular, among people living with HIV, healthcare
workers and/or their families.
• Optimal diagnostic algorithm for diagnosis of TB
following TB screening for IPT

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