Human Immunodeficiency Virus (HIV)

Overview

Human Immunodeficiency Virus (HIV) presents a complex knot for scientists to unravel। After initial contact and attachment to a cell of the immune system (e।g. lymphocytes, monocytes), there is a cascade of intracellular events. The endproduct of these events is the production of massive numbers of new viral particles, death of the infected cells, and ultimate devastation of the immune system. However, the knot IS becoming unraveled. These pages attempt to simplify HIV infection at the cellular level. The following diagram shows a number of steps from initial attachment of a viral particle to a lymphocyte through budding of new viruses from that cell.

Causes

The human immunodeficiency virus (HIV) can be spread by the following:

• Through sexual contact -- including oral, vaginal, and anal sex
• Through blood -- via blood transfusions (now very rare in the U.S.) or needle sharing
• From mother to child -- a pregnant woman can transmit the virus to her fetus through their shared blood circulation, or a nursing mother can pass it to her baby in her breast milk

People who become infected with HIV may have no symptoms for up to 10 years, but they can still pass the infection to others. After being exposed to the virus, it usually takes about 3 months for the HIV ELISA blood test to change from HIV negative to HIV positive.

HIV has spread throughout the U.S. The disease is more common in urban areas, especially in inner cities.

See also: AIDS for a more complete description of how AIDS is spread.