Sunday, October 28, 2012

answer the question of whether or not HIV

When this trial was stopped for futility because it lacked the power to answer the question of whether or not HIV-positive men who get circumcised are less likely to transmit HIV, it became clear that we would likely never know the definitive answer to this question. However, a key insight gained from the trial is the importance of sexual abstinence until complete wound healing. Premature resumption of sex may delay wound healing, increase the risk that a man may acquire a new HIV infection, and increase the risk of HIV transmission to sexual partners. These researchers previously found that 93% of HIV-positive men circumcised at CD4 › 350 cells were healed by 6 weeks post-circumcision. However, in this trial, 22% of couples resumed sex early and 25% of the men had not disclosed their HIV status, underscoring the importance of joint couple counselling and testing to learn serostatus and plan abstinence strategies for the healing period.

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